Age: 60
Occupation: Philanthropist and entrepreneur

In March, this former U.S. commerce secretary — and, in case you forgot, sister of the governor and friend of Barack Obama — announced she’d be chairing the Illinois COVID-19 Response Fund, which launched with $23 million in initial donations. Heir to the Hyatt Hotels empire, Pritzker has plenty of experience managing lots of money. She deployed a healthy portion of her fortune ($2.6 billion at last count) to fund the influential investment firm PSP Partners, which has directed hundreds of millions of dollars into both established businesses and promising startups. And through P33, her two-year-old tech-biz catalyst, Pritzker is on a mission to transform the city from tech hub to tech mecca.