Julia Stasch

For more than a decade, Stasch held the MacArthur Foundation’s purse strings, doling out billions. Now, after Robert Gallucci’s departure last July, she oversees everything.

Dean Harrison

With last summer’s merger of Northwestern and Cadence Health, Harrison now runs a four- hospital system (1,600 beds, 19,500 employees) with $3 billion in total revenue.

Jim Skinner

Now that the Deerfield-based chain has completed its 2012 megamerger with the European pharmacy giant Alliance Boots, the ex–McDonald’s CEO becomes the executive chairman of Walgreens Boots Alliance, an empire of 12,800 stores in 25 countries.

Linda Johnson Rice

With the publishing industry suffering, this magazine mogul has taken shrewd steps: expanding Ebony’s and Jet’s presence online and on mobile devices and mining the archives of classic photos and covers to create T-shirts and framed art for sale.

Curtis Duffy

At a time when celebrity chefs are turning to fried chicken, tacos, and burgers, Duffy brings refinement back: tablecloths, prix fixe menus, uncommon ingredients, and wine pairings. All this and three Michelin stars in only two years.

Craig Martin

Representing Fortune 500 companies and rich families, Martin got a $1 billion pension-loss case against Nuveen dismissed, bested former U.S. attorney Patrick Fitzgerald in court, and was picked to represent the Illinois Municipal League in state pension reform litigation.

Joseph Ferguson

Just when it looked like he was in the twilight of his career as Chicago’s chief public-corruption buster, he’s gotten a second life, with more money and power to investigate wrongdoing.

Howard Tullman

Starting 12 companies and turning around numerous others isn’t enough for this serial entrepreneur. Last year, he took over the nonprofit tech incubator 1871, helping to double its startup space in the Merchandise Mart.

Jorge Ramirez

With Bruce Rauner’s threats to take on “government union bosses,” the head honcho of one of the state’s largest unions—and a fixture on a slew of Rahm’s appointed task forces—will have lots of chances to flex his muscles.